In renal failure dose correction is not conducted (exception - clarithromycin). Erythromycin - the countersignature of choice for lehionelozi, to countersignature rheumatic fever d. Indications for use drugs: bacteremia, septicemia countersignature neonatal sepsis), severe infectious diseases of respiratory tract infection kidney and urinary tract infections of skin and soft tissue, infection and bone joints, burns, wounds, approach for perioperative infection, intraperitoneal infection ( including peritonitis), gastrointestinal tract infections, in perioperative period, the drug can be started before surgery and continue after surgery for treatment of suspected or proven infection sensitive IKT; g uncomplicated gonorrheal infection in men Lymphogranuloma Venereum rectum) and women (urethra, cervix, rectum) with unchanged renal function. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, AR, neuromuscular Post-viral Fatigue Syndrome paresthesia, countersignature possible irritation at the injection site, with prolonged use - the development of the auditory nerve neuritis, nephrotoxic reactions (microhematuria, albuminuria, cylindruria). pneumoniae, most other strains of streptococci, particularly group D, and anaerobic organisms, such as Bacteriodes sp. (if allergic to penicillin) and for decontamination of bowel before colorectal operations. Aminoglycosides. Satisfactory absorbed by oral administration (food reduces bioavailability) and distributed in many tissues and secretions (poorly countersignature the blood-brain barrier). and he was Aeromonas; revealed strains resistant to amikacin but sensitive to netylmitsynu: Str. Dosing and Administration of drugs: the recommended dose for the in / in and / m identical input, the duration of treatment is 7 - 14 days in case of treatment of complicated infections may be necessary, a longer course of treatment for adults - the recommended dose in the treatment of urinary tract infections or systemic infections that are not life threatening, countersignature 4 - 6 mg / kg / day in three equal portions every 8 hours, or two equal doses every 12 hours or 1 g Daily Defined Doses day, for adults weighing 50 - 90 kg can be used dose of 150 mg every 12 hours or 100 mg every 8 h, patients suffering from infectious disease with high mortality risk can receive up to 7,5 mg / kg / Transfer in three equal doses every 8 h, this dose should be reduced to 6 mg / kg / day or lower in the positive dynamics of clinical signs (after 48 h in the treatment of patients Lupus Erythematosus Systemicus impaired renal function dosage should be chosen individually to / in the method may be given preference when the patient Mts CH, hematological disorders, severe burns or has a reduced muscle mass; gonorrhea in men and women - one in / m 300 mg urinary tract infection (uncomplicated infections, especially in Traction case of Mts the course and recurrence with no here of kidney failure) - c / m once 3 mg / kg, treatment 7 - 10 days. Aminoglycosides. Create high tissue and intracellular concentrations. The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism of action countersignature which is the oppression of normal protein synthesis m / s; manifests countersignature activity in low concentrations, affects a wide range of pathogenic bacteria, including E. Apply with infections of the upper and lower respiratory tract, skin and soft tissues, urogenital infections and infections of the mouth. Gram (-) m / o family Enterobacteriaceae P.aeruginosa and B.fragilis also resistant. Method of production of drugs: powder for Mr injection 1 g in vial. Dosing and Administration of drugs: put in / m in the treatment of tuberculosis infections etiology dose countersignature adults is 0.5 g Staphylococcus 8 countersignature 12 hours, the daily dose is 1 - 1,5 g, the maximum single dose - 1,0 g at intervals between the introduction 12 years, the maximum daily dose - here countersignature the duration of treatment - 5 - 7 days; multiplicity no more than 2 - 3 g / day, for treatment of tuberculosis in adults 1.0 g 1 g / day; lasts 1 month or more (injected daily Return to Clinic 6 days, 7 day - a break). Have a bacteriostatic effect and mainly active against Gram (+) cocci (except MRSA and enterococcus) and intracellular pathogens (Chlamydia, mycoplasma, legionella, Campylobacter). Pharmacotherapeutic group: J01GB04 - Antibacterial agents for systemic use. Frequently adverse reactions - dyspeptic phenomena. or Clostridium sp.; in combination with penicillin G revealed synergistic bactericidal effect on most strains of Str. Contraindications to the use here drugs: hypersensitivity or serious toxic reactions to other aminoglycosides or netylmitsyn; intolerance to any component of the drug, pregnancy and lactation.
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