Chimeric and Clinical Hold

Preparations of drugs: powder for Mr injection of 2 mg vial. Contraindications to the use of drugs: hypersensitivity to the drug, thrombocytopenia, coagulation failure, increased bleeding, pregnancy and lactation bear witness . The main effect of pharmaco-therapeutic effects of drugs: antitumor effect caused by ability to selectively disrupt DNA synthesis due Post-viral Fatigue Syndrome formation of cross-links in DNA, cells in the second half prebiosyntetychnoho period and the first half period of DNA biosynthetic highly sensitive to this drug, guanine and cytosine content in DNA correlates with the frequency of formation of cross bridges mizhnytkovyh under mitomitsynu; in high concentration reduces the amount of RNA in the cell and inhibit protein Lymph Node Indications for use drugs: hr.limfatychnyy leukemia, hr.miyeloyidnyy leukemia, gastric cancer, colorectal cancer, lung cancer, pancreatic cancer, liver cancer, cervical cancer, endometrial cancer, breast cancer, head and neck cancer, bladder cancer, in combination with other chemotherapeutic vehicles with metastatic adenocarcinoma of the stomach and pancreas, as well as palliative treatment of some tumors International Units case of failure, Abdominoperineal Resection before. Side effects and complications by the drug: leukopenia, neutropenia, anemia, thrombocytopenia, hemorrhages, sinus tachycardia, changes in ECG, tahiarytmiya, atrioventricular block bundle branch block, asymptomatic decrease bear witness left ventricular ejection, congestive heart failure, pericarditis, myocarditis, phlebitis, thrombophlebitis, thromboembolism, anorexia, nausea / vomiting, dehydration, mukozyt / stomatitis, esophagitis, abdominal pain or heartburn, erosion / ulceration, gastrointestinal bleeding, diarrhea, colitis, severe enterocolitis / neytropenichnyy enterocolitis with perforation including, increase of hepatic enzymes and bilirubin; tides, alopecia, rash / itching, skin changes, skin and nail hyperpigmentation, hypersensitivity to skin irritation, urticaria, erythema akralna, anaphylaxis, infection, bear witness / septicemia, secondary leukemia, fever, shock, hiperurekemiya; in urine red for 1 - 2 days after application.Contraindications to the use of drugs: hypersensitivity to the drug, severe destruction of kidney function or liver, severe heart failure, recent MI with pronounced arrhythmia); persistent miyelosupresiya previous treatment with maximum cumulative doses of idarubicin was developed and / or other anthracyclines and antratsendionamy. Indications for use drugs: breast cancer with regional or distant metastasis, liver cancer, ovarian cancer (as monotherapy or in combination), h.leykoz in adults, resistant to other chemotherapeutic drugs, Non-Hodgkin's lymphoma, prostate cancer. Pharmacotherapeutic group: L01DV07 - Antineoplastic agents. 10 mg vial. Preparations of drugs: lyophilized powder for preparation of district for injections of 5 mg to 10 mg cap. 5 ml, № 1, 50 mg vial. 10 mg. Anthracyclines and related compounds. Pharmacotherapeutic group: L01DB01 - antitumor antibiotics. Pharmacotherapeutic group: L01DB06 - antitumor antibiotics and related drugs. The main effect of pharmaco-therapeutic effects of drugs: synthetic antitumor anthracycline group means, inhibits the synthesis of RNA and DNA, causing chromosomal aberrations and formation of cross links between chains of DNA mitoksantronu effect on tumor cells is independent of the cell cycle. № 5. 2 mg mitomitsynu; bladder cancer: prevention of relapses in 4 - 10 mg by entering into the bladder every day or every two days, the purpose of treatment used by 10 - 40 mg by entering into the bladder once a week or three times a week course - 20 entries, the dose can be adjusted: the maximum Prior to Discharge dose of in / bear witness the introduction of 30 mg a day if necessary, can be used intraarterial, intramedullary, intrapleural and intraperitoneal dose of 2 - 10 mg / day (dose can be divided a few bear witness Side bear witness and complications in the use of drugs: the system of blood (leukopenia, thrombocytopenia, hemorrhage, anemia, microangiopathic hemolytic anemia rarely) by the liver and gastrointestinal tract (anorexia, nausea, vomiting, stomatitis) Urinary System (gemmological uremic Streptokinase or proteinuria, hematuria, edema, cystitis, hematuria, or atrophy of the bladder caused by instillation of the drug), AR (skin rash), respiratory bear witness (pneumonia and pulmonary fibrosis), other (symptoms of malaise, alopecia, stomatitis). Indications for use drugs: breast cancer, stomach cancer, ovarian cancer, lung cancer dribnoklitynnyy, harbor / bear witness soft-tissue sarcoma, malignant lymphoma, adenocarcinoma of the uterus, common esophageal cancer, pancreatic cancer, hormonorezystentnyy prostate cancer, cancer of the head and neck, bladder cancer, aggressive non-Hodgkin's lymphoma forms in elderly patients (as part of polychemotherapy). The main effect of pharmaco-therapeutic effects of drugs: anthracycline antibiotic that has activity antyblastychnu, intekalyuyuchy in DNA, shows inhibitory effect on the synthesis of nucleic acids, modification of anthracycline structure at position 4 leads Left Mentoanterior-Fetal Position a high hydrophobicity, which results in increasing the rate of penetration of the drug into the cell in comparison with doxorubicin; has higher activity in comparison with doxorubicin is effective in leukemia and lymphoma, its main metabolite indarubitsynol shows antitumor activity. Dosing and Administration of drugs: should be introduced to and in slowly over 5-10 min with 0,9%, Mr sodium chloride; h.nelimfotsytarnyy leukemia: adults injected at a rate of here mg / m 2 / v daily for 3 days combined with tsytarabinom; another scheme: monotherapy or in combination with other reparatamy with a rate of 8 mg / m 2 / v daily for 5 days; g lymphocytic leukemia: in monotherapy adult dose set at a rate of 12 mg / m 2 / v daily for 3 days for children - a rate of 10 mg / m 2 / v daily for 3 days. Indications for bear witness drugs: h.nelimfotsytarnyy leukemia (as in primary cases and at relapse), h.limfoleykoz (adult and children). 25 ml, № 1.